Senior Manager, Commercial Accounting and Operations

Denali Therapeutics • South San Francisco, California • Full Time • $151,000–$196,000 / year

Posted on Tue, Sep 29, 2026

Denali Therapeutics Inc. is a biotechnology company pioneering a new class of biotherapeutics designed to cross the blood-brain barrier (BBB) using its proprietary TransportVehicle™ platform. With the first FDA-approved biologic specifically designed to cross the BBB, a clinically validated delivery platform and a growing portfolio of therapeutic candidates across all stages of development, we are advancing toward our goal of delivering effective medicines to transform the lives of people living with neurodegenerative diseases, lysosomal storage disorders and other serious diseases. 


We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.


Reporting to the Director, Commercial Finance, this role owns day-to-day execution across the commercial revenue cycle for our first commercial product, including order management, order-to-cash, accounts receivable and credit management, pricing operations, revenue recognition and gross-to-net reserves, and commercial-cycle close and controls. As the commercial footprint expands across products and geographies, this role is expected to build scalable, well-controlled processes rather than simply operate existing ones. This is a self-contributor role which expects to expand in the future as Denali scale and grow across the pipeline of drug candidates.

Key Accountabilities/Core Job Responsibilities:

Order Management, Revenue Recognition and Gross-to-Net (“GTN”)

Treasury Operations, Accounts Receivable and Credit Management

Technical Accounting and Contracts Review

Qualifications/Skills:

Preferred Experience

Salary Range: $151,000.00 to $196,000.00 .  Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at https://www.denalitherapeutics.com/careers

This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.

Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.

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  • Advertised pay for Senior Accounting Manager: a median of $142,500 across 388 priced postings. This posting advertises $151,000 to $196,000, 22% above that median. Explore the market

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