Internal Audit Manager

Vertex Pharmaceuticals • Boston, Massachusetts • Full Time • $111,700–$167,500 / year

Posted on Tue, Sep 22, 2026

Job Description

General Summary:

Through internal audits the Internal Audit Manager will identify risk areas, evaluate business process controls and complete test plans. Additionally, this role will provide recommendations to improve the effectiveness and efficiency of operations and business systems. This role will also participate in ensuring that the yearly internal control review is brought to fruition by interacting with SOX testers, other stakeholders, and subject matter experts on special projects and the development and execution of departmental goals.

Key Duties and Responsibilities:

  • Plans and performs financial, operational and, as applicable, IT audits; reviews related records for compliance with established and relevant reporting policies and procedures
  • Applies financial and quantitative analyses and risk assessment procedures, documents findings/work papers in support of departmental goals and objectives
  • Maintains and applies an understanding of generally accepted accounting principles/standards and/or general IT frameworks
  • Identifies and effectively communicates (both verbally and/or in writing) audit results, control weaknesses, accounting/reporting/application deficiencies, process or company risk, business productivity and efficiency opportunities, departmental vision, and any other relevant matters to management or other applicable parties
  • Reviews, appraises and tests the internal controls surrounding business processes to assess compliance with the Sarbanes-Oxley Act
  • Collaborates constructively and respectfully with fellow audit team members and business stakeholders including with multicultural teams and in global locations
  • Maintains communication with the Engagement Manager, responds to feedback and adjusts approach as the situation warrants
  • Contributes in management meetings, presents findings, conclusions and recommended actions to business management

    • Knowledge and Skills:

  • Experience within Life Sciences or related sector
  • Excellent organizational and project management skills
  • Excellent written and verbal communication skills
  • Detail oriented, able to multitask and meet deadlines
  • Able to work under general supervision and work collaboratively with diverse teams
  • Expanded knowledge of audit methodology, risk assessment and internal control concepts
  • Ability to analyze process workflows and identify gaps and bottleneck
  • Ability to perform data analytics, SOC1 reviews and understand ITGCs
  • Obtain and provide training to the audit staff to support all aspects of Internal Audit activities to ensure that approved audit objectives are met
  • Ability to operate effectively independently and in a team-oriented, multiple location environment
  • CPA, CIA or CISA certifications or equivalent a plus

    • Education and Experience:

  • Bachelor's degree in accounting/finance/information systems or related field
  • Typically requires 5+ years of auditing experience or the equivalent combination of education and experience.


    • At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

    Pay Range:

    $111,700 - $167,500

    Disclosure Statement:

    The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

    At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations.  From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

    Flex Designation:

    Hybrid-Eligible Or On-Site Eligible

    Flex Eligibility Status:

    In this Hybrid-Eligible role, you can choose to be designated as: 
    1.    Hybrid: work remotely up to two days per week; or select
    2.    On-Site: work five days per week on-site with ad hoc flexibility.

    Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. 

    Company Information

    Vertex is a global biotechnology company that invests in scientific innovation.

    Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

    Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

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